Research

For at least the last half-billion years, the earth’s biosphere has been rich in free oxygen: a product of photosynthesis. With the rise in free oxygen much of the biologically available...

The ribosome is a molecular machine responsible for synthesis of coded protein in all living systems. The ribosome is made of a small subunit (SSU) that decodes the messenger RNA and a large...

Comprised of both RNA and protein, the ribosome is a molecular fossil with a historical imprint in extant biochemistry.  Our goal is to reconstruct an in vivo model of an ancestral...

The ribosome is made of a small subunit (SSU) and a large subunit (LSU). The SSU in bacteria and archaea contains a single RNA molecule, the 16S rRNA. Phylogenic studies by Woese and coworkers (1...

Magnesium plays a special role in folding of large globular RNAs (1, 2). These RNAs are closely associated with magnesium ions, many of which can be visualized by X-ray diffraction. For example,...

 

The initial timelines indicate that the peptidyl transferase center (PTC) and parts of the 50S subunit emerged before any aspects of the 30S subunit. As the Fox group recently...

Desiccation tolerance in Rotifera One of the biggest challenges facing eukaryote extremophiles is the loss of water leading to desiccation.  Resistance to desiccation as adults,...

Ancestral EF-Tu proteins, resurrected previously by Eric Gaucher (7) exhibit a range of thermostability profiles (from 39.1 °C to 73.3 °C). During the first quarter of 2011, we finalized...

Initial sequence retrievals found inconsistent sequence annotation between Archaeal, Bacterial, and Eukaryal rProtein families. For example, Bacterial L33 is orthologous to the L44/L36 family in...

The ribosome, through highly coordinated and concerted movement, is responsible for the synthesis of all protein found within a cell.  In addition, it is so highly conserved that is can serve...

For the third year in a row, the Georgia Tech Team ran a one-week, non-residential Summer Learning Program (SLP), called Life on the Edge: Astrobiology. This year 19 high school students...

The Center for Ribosomal Origins and Evolution, along with the Center for Education Integrating Science, Mathematics, and Computing (CEISMC), Distance Learning and Professional Education (DLPE)...

The GT Center hosts many undergraduates and high school students in research labs run by the Co-PIs. These students frequently receive college credit for their research efforts. On a day-to-day...