Please join us for another session of the PCE3 seminar series on June 24 at 1:00-2:30 pm (EST). This session we are excited to hear from Tyler Roche and Bryce Clifton, both graduate students at the Georgia Institute of Technology. We will also have a short topical introduction from Dr. Nicholas Hud, Professor at the Georgia Institute of Technology. We hope you can join us for another exciting session!
Tyler Roche will talk about “The Key to Prebiotic Nucleoside Formation?”
Bryce Clifton will talk about “Achieving multiple rounds of nucleic acid replication in a prebiotic solvent: A solution to the product inhibition problem”
Please use this link to register. In the event the zoom meeting reaches capacity the meeting will be live streamed to the PCE3 youtube channel.
Spring 2021 Seminal Papers in Astrobiology schedule is now finalized! Guests, we welcome you to sit in on the presentations and discussions. Because this is a course with participation points given for students taking it for a grade, guests are asked to please reserve questions/comments until the end of the discussion period. Course meetings are Wednesdays 9:30-11:25 am Eastern on Blue Jeans: https://gatech.bluejeans.com/891027890
Abstract:Bacteroides thetaiotaomicron was examined to determine whether its obligate anaerobiosis is imposed by endogenous reactive oxygen species or by molecular oxygen itself. Previous analyses established that aerated B. thetaiotaomicron loses some enzyme activities due to a high rate of endogenous superoxide formation. However, the present study establishes that another key step in central metabolism is poisoned by molecular oxygen itself. Pyruvate dissimilation was shown to depend upon two enzymes, pyruvate:formate lyase (PFL) and pyruvate:ferredoxin oxidoreductase (PFOR), that lose activity upon aeration. PFL is a glycyl-radical enzyme whose vulnerability to oxygen is already understood. The rate of PFOR damage was unaffected by the level of superoxide or peroxide, showing that molecular oxygen itself is the culprit. The cell cannot repair PFOR, which amplifies the impact of damage. The rates of PFOR and fumarase inactivation are similar, suggesting that superoxide dismutase is calibrated so the oxygen- and superoxide-sensitive enzymes are equally sensitive to aeration. The physiological purpose of PFL and PFOR is to degrade pyruvate without disrupting the redox balance, and they do so using catalytic mechanisms that are intrinsically vulnerable to oxygen. In this way the anaerobic excellence and oxygen sensitivity of B. thetaiotaomicron are two sides of the same coin.
“AbGradCon (Astrobiology Graduate Conference) provides a unique setting for astrobiologically-inclined graduate students and early career researchers to come together to share their research, collaborate, and network. AbGradCon 2018 marks the 14th year of this conference–each time in a different place and organized by a different group of students, but always with the original charter as a guide.”
“These meetings have been wildly successful both when connected to AbSciCon, and as stand-alone conferences. Since it is organized and attended by only graduate students, post docs, and select undergraduates, AbGradCon is an ideal venue for the next generation of career astrobiologists to form bonds, share ideas, and discuss the issues that will shape the future of the field. Take a look at the AbGradCon 2017 conference website to see what’s happened in the past.”